Oxidants Stimulate Growth Factors
Rao GN. Division of Cardiology, University of Texas Medical Branch, Galveston
77555, USA. Oncogene. 1996 Aug 15; 13(4):713-9.
“Protein tyrosine phosphorylation events play determinant roles in cellular
processes such as proliferation and differentiation.”
"We have recently reported that hydrogen peroxide, an active oxygen species and
a cellular oxidant, stimulates growth response events in vascular smooth muscle
cells. Our findings show that hydrogen peroxide stimulates tyrosine
phosphorylation of several proteins including epidermal growth factor receptor.”
Oxidants Activate Growth Factor Receptors
Kai Chen, Shane R. Thomas, et al. Mitochondrial function is required for
hydrogen peroxide-induced growth factor receptor transactivation and downstream
signaling. J. Biol. Chem. 279(33):35079-35086.
“These data establish a novel role for the mitochondrion as a proximal target
specific to hydrogen peroxide-induced signaling and growth factor
Oxidants Mediate the Effects of Growth Factors
Ioan Cucoranu, Roza Clempus. Circulation Research. 2005;97:900-907.
“Intraforaminal O(2)-O(3) Versus Periradicular Steroidal Infiltrations in Lower
Back Pain: Randomized Controlled Study.”
Bonetti M, Fontana A, Cotticelli B, Volta GD, Guindani M, Leonardi M.. Am J
Neuroradiol. 2005 May; 26(5):996-1000.
“Painkilling Effect of Ozone-Oxygen Injection on Spine and Joint
Al-Jaziri AA, Mahmoodi SM, Saudi Med J. 2008 April;29(4):553-7. Departments of
Surgery, Rashid Hospital, Dubai, United Arab Emirates.
“Intramuscular Oxygen-Ozone Therapy in the Treatment of Acute Back Pain with
Lumbar Disc Herniation-a Multi-Center, Randomized, Double-Blind, Clinical Trial
of Active and Simulated Lumbar Paravertebral Injection.”
Marco Paoloni, MD, Luca Di Sante, MD, Angelo Cacchio, MD, et al., SPINE Volume
34, Number 13, pp 1337-1344, 2009.
“It should, nevertheless, be pointed out that the pathophysiology of LBP and
radicular pain has not yet been fully understood. Indeed, the mechanical effect
of nerve root compression does not seem to completely explain radicular pain.
Inflammatory changes have been observed in lumbar disc and periradicular tissues
in people suffering from lumbar and radiating pain, and a correlation has been
found between inflammatory changes in herniated lumbar disc specimen and outcome
after lumbar disc surgery, with a lower VAS rating in those patients showing
inflammatory changes in the herniated disc after surgery.”
Ozone vs placebo – 61% vs. 33% pain free
Fifth International Symposium on the Applications of Ozone, April 2007, Havana,
“Ozone Shot as Effective as Surgery for Herniated Disc."
As reported in CyberRounds, by Neil Wagner online at
A Toronto team examined the results of 12 previous studies involving over 8,000
patients of ozone treatment of herniated discs. The studies showed ozone therapy
to be just as effective as surgery but with a shorter recovery time and a much
lower risk of complications.